Developmentally Expressed Ca2+-sensitive Adenylyl Cyclase Activity Is Disrupted in the Brains of Type I Adenylyl Cyclase Mutant Mice
Intracellular cAMP plays a crucial role in various neuronal functions such as ion channel activity, transcription, and synaptic plasticity, with cAMP-dependent protein kinases being essential for long-term potentiation (LTP) in the hippocampus. The study highlights that Ca2+-stimulated adenylyl cyclase, particularly type I adenylyl cyclase (I-AC), is significantly upregulated during [...]
